Rakestraw Biotech Consulting Services
Expert guidance in drug discovery, protein engineering, and cell therapies for biotech and pharma companies.
Specialized in high-throughput platforms, library design, and next-generation engineering:
Protein engineering strategies and high-throughput display systems
Antibody and protein library design and screening approaches
Antibody discovery, optimization, and humanization
Cytokine engineering for function and expression
Engineering T-cell and B-cell agonists for function and solubility
Engineering CAR and receptors for specificity and altered function
Assay development for candidate screening and IND
Providing support for research, manufacturing, & regulatory functions in B- and T-cell therapies:
Research and early development for T- and B-cell therapies
Methods for ex vivo cell culture, training, and phenotype engineering
Analytic development in cell therapy for pre-clinical and GMP
Applied T- and B-cell engineering
Gene-editing with CRISPR and AAV
Analytic support for gene-edited cells
CMC team-building, strategy and bulidout
CDMO and CRO management
Empowerment with strategy and support from discovery to the clinic:
Design and implementation of potency assays for IND and GMP manufacturing
pre-IND and IND authorship and FDA interactions
CMC strategy for IND and Phase I manufacturing
CDMO/CRO vetting, engagement, and management
Pre-clinical report writing for Module 4
Studies for mechanism of action
Dose calculations
Biologic and cell therapy study design
Module 3 IND Authorship
